Publications by RCLR members (2016)

Arnaoutis, G., Kavouras, S. A., Stratakis, N., Likka, M., Mitrakou, A., Papamichael, C., Sidossis, L. S., and Stamatelopoulos, K. (2016) The effect of hypohydration on endothelial function in young healthy adults. Eur. J. Nutr.

Atilano-Roque, A., Aleksunes, L. M., and Joy, M. S. (2016) Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury. Toxicol. Lett. 259, 52-59

Basu, D., Kahn, J. N., Li, X. P., and Tumer, N. E. (2016) Conserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome. Infect. Immun. 84, 3290-3301

Bircsak, K. M., Gupta, V., Yuen, P. Y., Gorczyca, L., Weinberger, B. I., Vetrano, A. M., and Aleksunes, L. M. (2016) Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter. J. Pharmacol. Exp. Ther. 357, 103-113

Brasaemle, D. L. and Wolins, N. E. (2016) Isolation of Lipid Droplets from Cells by Density Gradient Centrifugation. Curr. Protoc. Cell Biol. 72, 3

Bright, A. S., Herrera-Garcia, G., Moscovitz, J. E., You, D., Guo, G. L., and Aleksunes, L. M. (2016) Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation. Nucl. Receptor Res. 3,

Brunetti, L., Sanchez-Catanese, B., Kagan, L., Wen, X., Liu, M., Buckley, B., Luyendyk, J. P., and Aleksunes, L. M. (2016) Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting. Thromb. J. 14, 10

Brunetti, L., Kagan, L., Forrester, G., Aleksunes, L. M., Lin, H., Buyske, S., and Nahass, R. G. (2016) Cefoxitin Plasma and Subcutaneous Adipose Tissue Concentration in Patients Undergoing Sleeve Gastrectomy. Clin. Ther. 38, 204-210

Bunpo, P. and Anthony, T. G. (2016) Ascorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exercise program. Appl. Physiol Nutr. Metab 41, 175-180

Campbell, S. C., Wisniewski, P. J., Noji, M., McGuinness, L. R., Haggblom, M. M., Lightfoot, S. A., Joseph, L. B., and Kerkhof, L. J. (2016) The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice. PLoS. One. 11, e0150502

Chen, Y., Clarke, O. B., Kim, J., Stowe, S., Kim, Y. K., Assur, Z., Cavalier, M., Godoy-Ruiz, R., von, A., Manzini, C., Blaner, W. S., Frank, J., Quadro, L., Weber, D. J., Shapiro, L., Hendrickson, W. A., and Mancia, F. (2016) Structure of the STRA6 receptor for retinol uptake. Science 353,

Chondronikola, M., Volpi, E., Borsheim, E., Porter, C., Saraf, M. K., Annamalai, P., Yfanti, C., Chao, T., Wong, D., Shinoda, K., Labbe, S. M., Hurren, N. M., Cesani, F., Kajimura, S., and Sidossis, L. S. (2016) Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metab 23, 1200-1206

Chondronikola, M., Volpi, E., Borsheim, E., Chao, T., Porter, C., Annamalai, P., Yfanti, C., Labbe, S. M., Hurren, N. M., Malagaris, I., Cesani, F., and Sidossis, L. S. (2016) Brown Adipose Tissue Is Linked to a Distinct Thermoregulatory Response to Mild Cold in People. Front Physiol  7, 129

Costabile, B. K., Kim, Y. K., Iqbal, J., Zuccaro, M. V., Wassef, L., Narayanasamy, S., Curley, R. W., Jr., Harrison, E. H., Hussain, M. M., and Quadro, L. (2016) beta-Apo-10'-carotenoids Modulate Placental Microsomal Triglyceride Transfer Protein Expression and Function to Optimize Transport of Intact beta-Carotene to the Embryo. J. Biol. Chem. 291, 18525-18535

Davidson, C. D., Fishman, Y. I., Puskas, I., Szeman, J., Sohajda, T., McCauliff, L. A., Sikora, J., Storch, J., Vanier, M. T., Szente, L., Walkley, S. U., and Dobrenis, K. (2016) Efficacy and ototoxicity of different cyclodextrins in Niemann-Pick C disease. Ann. Clin. Transl. Neurol.  3, 366-380

Ding, R., Jin, S., Pabon, K., and Scotto, K. W. (2016) A role for ABCG2 beyond drug transport: Regulation of autophagy. Autophagy. 12, 737-751

Fry, C. S., Porter, C., Sidossis, L. S., Nieten, C., Reidy, P. T., Hundeshagen, G., Mlcak, R., Rasmussen, B. B., Lee, J. O., Suman, O. E., Herndon, D. N., and Finnerty, C. C. (2016) Satellite cell activation and apoptosis in skeletal muscle from severely burned children. J. Physiol 594, 5223-5236

Fusakio, M. E., Willy, J. A., Wang, Y., Mirek, E. T., Al Baghdadi, R. J., Adams, C. M., Anthony, T. G., and Wek, R. C. (2016) Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol. Biol. Cell 27, 1536-1551

George, B., Wen, X., Mercke, N., Gomez, M., O'Bryant, C., Bowles, D. W., Hu, Y., Hogan, S. L., Joy, M. S., and Aleksunes, L. M. (2016) Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-Dependent Changes in the Absence of Clinical Nephrotoxicity. Clin. Pharmacol. Ther.

Gietzen, D. W., Anthony, T. G., Fafournoux, P., Maurin, A. C., Koehnle, T. J., and Hao, S. (2016) Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing. Cell Rep. 16, 2049-2050

Grammatikopoulou, M. G., Maraki, M. I., Giannopoulou, D., Poulimeneas, D., Sidossis, L. S., and Tsigga, M. (2016) Similar Mediterranean diet adherence but greater central adiposity is observed among Greek diaspora adolescents living in Istanbul, compared to Athens. Ethn. Health 1-12

Hardman, D., McFalls, D., and Fakas, S. (2016) Characterization of phosphatidic acid phosphatase activity in the oleaginous yeast Yarrowia lipolytica and its role in lipid biosynthesis. Yeast

Hsieh, L.-S., Su, W.-M., Han, G.-S., and Carman, G. M. (2016) Phosphorylation of yeast Pah1 phosphatidate phosphatase by casein kinase II regulates its function in lipid metabolism. J. Biol. Chem. 291, 9974-9990

Huang, W., Liao, G., Baker, G. M., Wang, Y., Lau, R., Paderu, P., Perlin, D. S., and Xue, C. (2016) Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans. MBio. 7,

Jetzt, A. E., Li, X. P., Tumer, N. E., and Cohick, W. S. (2016) Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome. Toxicol. Appl. Pharmacol. 310, 120-128

Kaya, S., Basta-Pljakic, J., Seref-Ferlengez, Z., Majeska, R. J., Cardoso, L., Bromage, T., Zhang, Q., Flach, C. R., Mendelsohn, R., Yakar, S., Fritton, S. P., and Schaffler, M. B. (2016) Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue. J. Bone Miner. Res.

Kong, B., Zhu, Y., Li, G., Williams, J. A., Buckley, K., Tawfik, O., Luyendyk, J. P., and Guo, G. L. (2016) Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis. Am. J. Physiol Gastrointest. Liver Physiol 310, G295-G302

Lin, Y., Bircsak, K. M., Gorczyca, L., Wen, X., and Aleksunes, L. M. (2016) Regulation of the placental BCRP transporter by PPAR gamma.  J. Biochem. Mol. Toxicol.

Magkouta, S., Pappas, A., Moschos, C., Vazakidou, M. E., Psarra, K., and Kalomenidis, I. (2016) Icmt inhibition exerts anti-angiogenic and anti-hyperpermeability activities impeding malignant pleural effusion. Oncotarget. 7, 20249-20259

McCourt, P., Liu, H. Y., Parker, J. E., Gallo-Ebert, C., Donigan, M., Bata, A., Giordano, C., Kelly, S. L., and Nickels, J. T., Jr. (2016) Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3. (Bethesda.)

Memon, N., Weinberger, B. I., Hegyi, T., and Aleksunes, L. M. (2016) Inherited disorders of bilirubin clearance. Pediatr. Res. 79, 378-386

Moscovitz, J. E., Kong, B., Buckley, K., Buckley, B., Guo, G. L., and Aleksunes, L. M. (2016) Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064. Toxicol. Appl. Pharmacol. 310, 60-67

Moscovitz, J. E., Nahar, M. S., Shalat, S. L., Slitt, A. L., Dolinoy, D. C., and Aleksunes, L. M. (2016) Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers. Drug Metab Dispos. 44, 1061-1065

Ogunbileje, J. O., Porter, C., Herndon, D. N., Chao, T., Abdelrahman, D. R., Papadimitriou, A., Chondronikola, M., Zimmers, T. A., Reidy, P. T., Rasmussen, B. B., and Sidossis, L. S. (2016) Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma. Am. J. Physiol Endocrinol. Metab 311, E436-E448

Panagiotopoulos, N., Lagoudianakis, E., Pappas, A., Filis, K., Salemis, N., Manouras, A., Kontzoglou, K., and Zografos, G. (2016) Lymphovascular infiltration in the tumor bed is a useful marker of biological behavior in breast cancer. J. BUON. 21, 1082-1089

Pappas, A., Liakou, A., and Zouboulis, C. C. (2016) Nutrition and skin. Rev. Endocr. Metab Disord. 17, 443-448

Patel, M. A., Luo, F., Khoshi, M. R., Rabie, E., Zhang, Q., Flach, C. R., Mendelsohn, R., Garfunkel, E., Szostak, M., and He, H. (2016) P-Doped Porous Carbon as Metal Free Catalysts for Selective Aerobic Oxidation with an Unexpected Mechanism. ACS Nano. 10, 2305-2315

Peng, L., Piekos, S., Guo, G. L., and Zhong, X. B. (2016) Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver. Acta Pharm. Sin. B 6, 453-459

Porter, C., Tompkins, R. G., Finnerty, C. C., Sidossis, L. S., Suman, O. E., and Herndon, D. N. (2016) The metabolic stress response to burn trauma: current understanding and therapies. Lancet 388, 1417-1426

Porter, C., Herndon, D. N., Chondronikola, M., Chao, T., Annamalai, P., Bhattarai, N., Saraf, M. K., Capek, K. D., Reidy, P. T., Daquinag, A. C., Kolonin, M. G., Rasmussen, B. B., Borsheim, E., Toliver-Kinsky, T., and Sidossis, L. S. (2016) Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function. Cell Metab 24, 246-255

Porter, C., Herndon, D. N., Elizonda, A., Bhattarai, N., Capek, K. D., Sidossis, L. S., and Suman, O. E. (2016) Rehabilitative Exercise Training Increases Skeletal Muscle Contractile and Metabolic Function in Severely Burned Children: 2096 Board #248 June 2, 2: 00 PM - 3: 30 PM. Med. Sci. Sports Exerc. 48, 589

Porter, C., Herndon, D. N., Bhattarai, N., Ogunbileje, J. O., Szczesny, B., Szabo, C., Toliver-Kinsky, T., and Sidossis, L. S. (2016) Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics. Burns 42, 112-122

Pyatski, Y., Zhang, Q., Mendelsohn, R., and Flach, C. R. (2016) Effects of permeation enhancers on flufenamic acid delivery in Ex vivo human skin by confocal Raman microscopy. Int. J. Pharm. 505, 319-328

Qiu, Y., Hassaninasab, A., Han, G.-S., and Carman, G. M. (2016) Phosphorylation of Dgk1 diacylglycerol kinase by casein kinase II regulates phosphatidic acid production in Saccharomyces cerevisiae. J. Biol. Chem. 291, 26455-26467

Quadro, L. (2016) A Gold Standard to Accurately Assess Vitamin A Status: Are We There Yet? J. Nutr. 146, 1929-1930

Ratamess, N. A., Bush, J. A., Kang, J., Kraemer, W. J., Stohs, S. J., Nocera, V. G., Leise, M. D., Diamond, K. B., Campbell, S. C., Miller, H. B., and Faigenbaum, A. D. (2016) The Effects of Supplementation with p-Synephrine Alone and in Combination with Caffeine on Metabolic, Lipolytic, and Cardiovascular Responses during Resistance Exercise. J. Am. Coll. Nutr.  35, 657-669

Rosanoff, A., Dai, Q., and Shapses, S. A. (2016) Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Adv. Nutr. 7, 25-43

Schumacher, J. D. and Guo, G. L. (2016) Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors. Biomed. Res. Int. 2016, 8323747

Shabrova, E., Hoyos, B., Vinogradov, V., Kim, Y. K., Wassef, L., Leitges, M., Quadro, L., and Hammerling, U. (2016) Retinol as a cofactor for PKCdelta-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity. FASEB J. 30, 1339-1355

Shete, V., Costabile, B. K., Kim, Y. K., and Quadro, L. (2016) Low-Density Lipoprotein Receptor Contributes to beta-Carotene Uptake in the Maternal Liver. Nutrients. 8,

Sofou, S. and Borden, M. (2016) Journal of Membrane Biology: Biotechnology and Engineering Section. J. Membr. Biol. 249, 7

Stras, S., Holleran, T., Howe, A., and Sofou, S. (2016) Interstitial Release of Cisplatin from Triggerable Liposomes Enhances Efficacy against Triple Negative Breast Cancer Solid Tumor Analogues. Mol. Pharm. 13, 3224-3233

Szilagyi, J. T., Mishin, V., Heck, D. E., Jan, Y. H., Aleksunes, L. M., Richardson, J. R., Heindel, N. D., Laskin, D. L., and Laskin, J. D. (2016) Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. Toxicol. Sci. 151, 150-159

Temprano, A., Sembongi, H., Han, G. S., Sebastian, D., Capellades, J., Moreno, C., Guardiola, J., Wabitsch, M., Richart, C., Yanes, O., Zorzano, A., Carman, G. M., Siniossoglou, S., and Miranda, M. (2016) Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes. Diabetologia 59, 1985-1994

Udasin, R. G., Wen, X., Bircsak, K. M., Aleksunes, L. M., Shakarjian, M. P., Kong, A. N., Heck, D. E., Laskin, D. L., and Laskin, J. D. (2016) Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1). Toxicol. Sci.  149, 202-212

Villasmil, M. L., Francisco, J., Gallo-Ebert, C., Donigan, M., Liu, H. Y., Brower, M., and Nickels, J. T., Jr. (2016) Ceramide signals for initiation of yeast mating-specific cell cycle arrest. Cell Cycle  15, 441-454

Wanders, D., Stone, K. P., Forney, L. A., Cortez, C. C., Dille, K. N., Simon, J., Xu, M., Hotard, E. C., Nikonorova, I. A., Pettit, A. P., Anthony, T. G., and Gettys, T. W. (2016) Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction. Diabetes 65, 1499-1510

Wang, Y., Dellatore, P., Douard, V., Qin, L., Watford, M., Ferraris, R. P., Lin, T., and Shapses, S. A. (2016) High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice. Nutr. Res. 36, 742-750

Xu, H., Zhou, X., Wen, X., Lauer, F. T., Liu, K. J., Hudson, L. G., Aleksunes, L. M., and Burchiel, S. W. (2016) Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells. Toxicol. Sci. 149, 31-41

Zhu, C., Bandekar, A., Sempkowski, M., Banerjee, S. R., Pomper, M. G., Bruchertseifer, F., Morgenstern, A., and Sofou, S. (2016) Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues. Mol. Cancer Ther. 15, 106-113

Zhu, Y., Liu, H., Zhang, M., and Guo, G. L. (2016) Fatty liver diseases, bile acids, and FXR. Acta Pharm. Sin. B 6, 409-412